WATSON, J. D. (+) F. H. C. CRICK (+) M. H. F. WILKINS (+) A. R. STOKES (+) H. R. WILSON (+) R. E. FRANKLIN (+) R. G. GOSLING

Molecular Structure of Nucleic Acids - A Structure for Deoxyribose Nucleic Acid (+) Molecular Structure of Deoxypentose Nucleic Acids (+) Molecular Configuration in Sodium Thymonucleate (+) Genetical Implications of the Structure of Deoxyribonucleic Acid (+) Evidence for 2-Chain Helix in Crystalline Structure Sodium Deoxyribonucleate (+) Helical Structure of Crystalline Deoxypentose Nucleic Acid.

London, Macmillan, 1953.

Royal8vo. 2 volumes uniformly bound in contemporary half cloth with gilt lettering to spines. In "Nature", Vol. 171 & 172, 1953, entire volumes offered. A stamp to lower part of each title-page, and light soiling to lower part of fore edges, otherwise a fine and clean set. Vol. 171: Pp. 737-38; 738-40; 740-41; 964-67; 156-57. Vol. 172: Pp. 759-62.

First edition of Watson and Crick's groundbreaking work, arguably the most important discovery in biology since Darwin, in which he presented the discovery of DNA for which the author, Francis Crick and Maurice Wilkins were awarded the Nobel Prize in Medicine in 1962. The identification of the double helix structure of DNA made it possible to understand the transfer of living matter from one generation to the next, with far-reaching implications.

Here he “records the discovery of the molecular structure of deoxyribonucleic acid (DNA), the main component of chromosomes and the material that transfers genetic characteristics in all life forms. Publication of this paper initiated the science of molecular biology. Forty years after Watson and Crick's discovery, so much of the basic understanding of medicine and disease has advanced to the molecular level that their paper may be considered the most significant single contribution to biology and medicine in the twentieth century” (One Hundred Books Famous in Medicine, p. 362).

“The double helix put genetics on a physical footing that would shed light on almost every aspect of modern biology and medicine. Examples include the migration of human populations throughout history; ecology and biodiversity; cancer-causing mutations in tumours and their drug treatment; surveillance of microbial drug resistance in hospitals and the global population; and the diagnosis and treatment of rare congenital diseases. DNA analysis has long been established in forensics, and research into more-futuristic applications, such as DNA-based computing, is well advanced.
Paradoxically, Watson and Crick’s iconic structure has also made it possible to recognize the shortcomings of the central dogma, with the discovery of small RNAs that can regulate gene expression, and of environmental factors that induce heritable epigenetic change. No doubt, the concept of the double helix will continue to underpin discoveries in biology for decades to come.” (Ferry, The Structure of DNA, 2019)

Grolier Club, One Hundred Books Famous in Medicine, 99
Dibner, Heralds of Science, 200
Garrison-Morton 256.3, 7138 for Watson & Crick papers, 6847 for the Franklin & Gosling paper.
Gedeon, p. 457.

Order-nr.: 59903

DKK 30.000,00